NeuroMotor PenTM Report

Published

March 15, 2023

Parkinson’s Disease Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID pg36
Test date and time 2018-01-26 10:34
Test battery template_05_subset_00, template_02_subset_00, Template_elel, template_06_subset_00, template_06_subset_04, template_04_subset_00, template_04_subset_00_offset, template_00_subset_00 (format)

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 41 individuals with a value less than 0.85 were subsequently diagnosed with PD. That is, 97.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.85 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 19, 'TN': 13, 'TP': 23, 'FP': 17}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 4, 'TN': 5, 'TP': 38, 'FP': 25}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 9, 'TN': 8, 'TP': 33, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Test Battery Details

Circle

numCircles 5
timePerCircleMean 8.112
timePerCircleCoV 0.114766
timePerCircleSlope -0.0710059
meanError 4.6466
tremorFreq 5.95703
tremorRelPower 21.4217
tremorGyroAmpMean 0.0114083
tremorGyroAmpSlope 0.00648988
tremorGyroAmpCoV 0.330261
tremorCoordAmpMean 0.0353583
tremorCoordAmpSlope 0.00735492
tremorCoordAmpCoV 0.263049
tremorAccAmpMean 0.0205
tremorAccAmpSlope 0.000607849
tremorAccAmpCoV 0.340674
tremorPcRelVar 0.76002
tremorPcX 0.238166
tremorPcY 0.971225

Circle Segment 1

Duration 9.48 s, Accuracy Estimate 3.898 (lower is better)

Circle Segment 2

Duration 8.56 s, Accuracy Estimate 4.122 (lower is better)

Circle Segment 3

Duration 7.92 s, Accuracy Estimate 4.383 (lower is better)

Circle Segment 4

Duration 7.44 s, Accuracy Estimate 5.246 (lower is better)

Circle Segment 5

Duration 7.16 s, Accuracy Estimate 5.585 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 27.1289
timePerSpiralCoV 0.131053
timePerSpiralSlope -0.0038827
meanError 3.20489
tremorFreq 5.85938
tremorRelPower 28.9616
tremorGyroAmpMean 0.0145371
tremorGyroAmpSlope -0.000557985
tremorGyroAmpCoV 0.359754
tremorCoordAmpMean 0.0308938
tremorCoordAmpSlope -0.000741649
tremorCoordAmpCoV 0.442744
tremorAccAmpMean 0.0471306
tremorAccAmpSlope -0.000347574
tremorAccAmpCoV 0.134123
tremorPcRelVar 0.744855
tremorPcX 0.162044
tremorPcY -0.986784

Spiral Segment 1

Duration 21.0 s, Accuracy Estimate 6.557 (lower is better)

Spiral Segment 2

Duration 29.32 s, Accuracy Estimate 2.716 (lower is better)

Spiral Segment 3

Duration 32.28 s, Accuracy Estimate 2.649 (lower is better)

Spiral Segment 4

Duration 28.36 s, Accuracy Estimate 2.814 (lower is better)

Spiral Segment 5

Duration 25.2 s, Accuracy Estimate 2.786 (lower is better)

Spiral Segment 6

Duration 30.72 s, Accuracy Estimate 3.045 (lower is better)

Spiral Segment 7

Duration 28.04 s, Accuracy Estimate 2.967 (lower is better)

Spiral Segment 8

Duration 25.2 s, Accuracy Estimate 2.617 (lower is better)

Spiral Segment 9

Duration 24.04 s, Accuracy Estimate 2.695 (lower is better)

Elel

eDurationMean 0.712179
eDurationStd 0.14392
eDurationStdnorm 0.202084
eDurationMedian 0.705
eDurationQuartdelta 0.16125
eDurationQuartdeltanorm 0.228723
eDurationKurt 3.33736
eDurationTrenddiff -0.105
eDurationTrendratio 0.864516
eWidthMean 4.23959
eWidthStd 1.43261
eWidthStdnorm 0.337913
eWidthMedian 4.05749
eWidthQuartdelta 1.89664
eWidthQuartdeltanorm 0.467441
eWidthKurt 3.26516
eWidthTrenddiff -1.1357
eWidthTrendratio 0.758765
eHeightMean 9.41405
eHeightStd 1.94208
eHeightStdnorm 0.206296
eHeightMedian 9.36202
eHeightQuartdelta 2.24002
eHeightQuartdeltanorm 0.239267
eHeightKurt 3.14869
eHeightTrenddiff -2.02874
eHeightTrendratio 0.809654
eAspectMean 0.454905
eAspectStd 0.130775
eAspectStdnorm 0.287478
eAspectMedian 0.461779
eAspectQuartdelta 0.208753
eAspectQuartdeltanorm 0.452063
eAspectKurt 2.22668
eAspectTrenddiff -0.0756123
eAspectTrendratio 0.855864
eSlantMean -0.172294
eSlantStd 0.216839
eSlantStdnorm -1.25854
eSlantMedian -0.174807
eSlantQuartdelta 0.261212
eSlantQuartdeltanorm -1.49429
eSlantKurt 3.06058
eSlantTrenddiff -0.0763136
eRtopMean 0.751668
eRtopStd 0.17648
eRtopStdnorm 0.234785
eRtopMedian 0.78593
eRtopQuartdelta 0.2316
eRtopQuartdeltanorm 0.294682
eRtopKurt 3.2292
eRtopTrenddiff 0.0194809
eRbotMean 1.23017
eRbotStd 0.549066
eRbotStdnorm 0.446335
eRbotMedian 1.10248
eRbotQuartdelta 0.596759
eRbotQuartdeltanorm 0.541286
eRbotKurt 3.273
eRbotTrenddiff 0.154077
eRrightMean 0.858839
eRrightStd 0.104241
eRrightStdnorm 0.121375
eRrightMedian 0.88551
eRrightQuartdelta 0.161712
eRrightQuartdeltanorm 0.18262
eRrightKurt 4.03126
eRrightTrenddiff 0.0219786
eRleftMean 0.535251
eRleftStd 0.114304
eRleftStdnorm 0.213553
eRleftMedian 0.537754
eRleftQuartdelta 0.148056
eRleftQuartdeltanorm 0.275323
eRleftKurt 2.44043
eRleftTrenddiff 0.0825664
lDurationMean 0.841143
lDurationStd 0.193277
lDurationStdnorm 0.229779
lDurationMedian 0.79
lDurationQuartdelta 0.24625
lDurationQuartdeltanorm 0.311709
lDurationKurt 3.77636
lDurationTrenddiff -0.26
lDurationTrendratio 0.733333
lWidthMean 6.38009
lWidthStd 1.49819
lWidthStdnorm 0.234823
lWidthMedian 5.96002
lWidthQuartdelta 2.03117
lWidthQuartdeltanorm 0.340799
lWidthKurt 2.52328
lWidthTrenddiff -1.33955
lWidthTrendratio 0.810959
lHeightMean 21.3932
lHeightStd 4.64582
lHeightStdnorm 0.217164
lHeightMedian 20.4136
lHeightQuartdelta 3.98346
lHeightQuartdeltanorm 0.195138
lHeightKurt 6.36287
lHeightTrenddiff -1.15512
lHeightTrendratio 0.944933
lAspectMean 0.303017
lAspectStd 0.0654483
lAspectStdnorm 0.215989
lAspectMedian 0.301474
lAspectQuartdelta 0.0894577
lAspectQuartdeltanorm 0.296734
lAspectKurt 2.31651
lAspectTrenddiff -0.000550585
lAspectTrendratio 0.998174
lSlantMean -0.0549141
lSlantStd 0.0998826
lSlantStdnorm -1.81889
lSlantMedian -0.038178
lSlantQuartdelta 0.125238
lSlantQuartdeltanorm -3.28036
lSlantKurt 3.05582
lSlantTrenddiff -0.0404954
lRtopMean 0.873996
lRtopStd 0.0918074
lRtopStdnorm 0.105043
lRtopMedian 0.883364
lRtopQuartdelta 0.139395
lRtopQuartdeltanorm 0.157801
lRtopKurt 3.49725
lRtopTrenddiff -0.0040192
lRbotMean 1.10191
lRbotStd 0.384816
lRbotStdnorm 0.349227
lRbotMedian 1.03775
lRbotQuartdelta 0.45358
lRbotQuartdeltanorm 0.43708
lRbotKurt 4.80424
lRbotTrenddiff 0.214431
lRrightMean 0.901517
lRrightStd 0.0694256
lRrightStdnorm 0.0770098
lRrightMedian 0.911222
lRrightQuartdelta 0.137188
lRrightQuartdeltanorm 0.150554
lRrightKurt 1.65115
lRrightTrenddiff 0.0765722
lRleftMean 0.473762
lRleftStd 0.071361
lRleftStdnorm 0.150626
lRleftMedian 0.481107
lRleftQuartdelta 0.0946444
lRleftQuartdeltanorm 0.196722
lRleftKurt 2.38484
lRleftTrenddiff 0.067549

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

Can’t do fitts_short because ‘fitts_short’

FITTS Long Modified

Can’t do fitts_long because ‘fitts_long’

ZigZag

numZigzags 5
timePerZigzagMean 16.256
timePerZigzagCoV 0.113611
timePerZigzagSlope 0.0644685
meanError 4.24105
tremorFreq 6.25
tremorRelPower 22.1604
tremorGyroAmpMean 0.0185531
tremorGyroAmpSlope -0.00695204
tremorGyroAmpCoV 0.265116
tremorCoordAmpMean 0.0368944
tremorCoordAmpSlope -0.0058165
tremorCoordAmpCoV 0.298827
tremorAccAmpMean 0.0767773
tremorAccAmpSlope -0.00128125
tremorAccAmpCoV 0.0719115
tremorPcRelVar 0.742063
tremorPcX 0.0969638
tremorPcY 0.995288

ZigZag Segment 1

Duration 15.08 s, Accuracy Estimate 5.399 (lower is better)

ZigZag Segment 2

Duration 14.52 s, Accuracy Estimate 4.401 (lower is better)

ZigZag Segment 3

Duration 15.24 s, Accuracy Estimate 3.938 (lower is better)

ZigZag Segment 4

Duration 17.72 s, Accuracy Estimate 4.511 (lower is better)

ZigZag Segment 5

Duration 18.72 s, Accuracy Estimate 2.957 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.104
timePerZigzagCoV 0.116946
timePerZigzagSlope -0.0581626
zigzagHeightMean 37.9506
zigzagHeightCoV 0.183999
zigzagHeightSlope -0.102285
meanError 0.0506816
tremorFreq 6.15234
tremorRelPower 29.9934
tremorGyroAmpMean 0.0227856
tremorGyroAmpSlope -0.00409874
tremorGyroAmpCoV 0.295019
tremorCoordAmpMean 0.0449357
tremorCoordAmpSlope -0.00100492
tremorCoordAmpCoV 0.322861
tremorAccAmpMean 0.0779853
tremorAccAmpSlope -0.000759731
tremorAccAmpCoV 0.109253
tremorPcRelVar 0.754074
tremorPcX 0.189139
tremorPcY 0.98195

ZigZag Offset Segment 1

Duration 13.68 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 2

Duration 13.56 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 3

Duration 10.96 s, Accuracy Estimate 0.07 (lower is better)

ZigZag Offset Segment 4

Duration 10.76 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 5

Duration 11.56 s, Accuracy Estimate 0.04 (lower is better)

sentence

Can’t do sentence because ‘sentence’

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.67}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.85}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5302306733632567}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.934793936423459}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7901971247215468}